Indoline derivatives substituted in position 6, production...

Details Indoline derivatives substituted in position 6, production... Indoline derivatives substituted in position 6, production...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4025 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/4045 (2006.01) A61K 31/4427 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 209/34 (2006.01) C07D 209/48 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2493721

The invention relates to indoline derivatives substituted in position 6 of general formula (I) wherein R1 - R6 and X are defined in Claim 1, the tautomers, enantiomers, diastomers thereof, the mixtures and salts thereof, especially physiologically compatible salts which have valuable pharamaceutical properties, especially an inhibiting effect on various receptor tyrosine kinases and on the proliferation of enthethelial cells and various tumor cells, medicaments containing said compounds, the use thereof and a method for the production thereof.

L'invention concerne des dérivés d'indolinone substitués en position 6, de formule générale (I), dans laquelle R¿1? à R¿6? et X ont la définition mentionnée dans la revendication (1), leurs tautomères, énantiomères, diastéréomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement acceptables, qui présentent des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur différents récepteurs à tyrosine kinase, et sur la prolifération de cellules endothéliales et de différentes cellules tumorales. L'invention concerne également des médicaments contenant lesdits composés, l'utilisation de ces derniers et des procédés pour la préparation desdits composés.

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