Indoline derivatives useful as 5-ht-2c receptor antagonists

Details Indoline derivatives useful as 5-ht-2c receptor antagonists Indoline derivatives useful as 5-ht-2c receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) C07D 213/72 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2258240

The invention relates to heterocyclic compounds of formula (I) or a salt thereof wherein X is CH or N; R1 is hydrogen or C1-6 alkyl; R2 and R3 groups are independently halogen, C1-6 alkyl, or trifluoromethyl, having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders such as anxiety.

L'invention concerne des composés hétérocycliques de formule (I), dans laquelle X est CH ou N; R?1¿ est hydrogène ou alkyle C¿1?-C¿6?; et les groupes R?2¿ et R?3¿ sont indépendamment halogène, alkyle C¿1?-C¿6? ou trifluorométhyle; et leurs sels; ces composés ayant une activité pharmacologique. L'invention concerne également des procédés permettant de les préparer et des compositions les contenant, ainsi que leur utilisation dans le traitement des troubles du système nerveux central tels que l'angoisse.

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