Indoline derivatives useful as 5-ht-2c receptor antagonists

Details Indoline derivatives useful as 5-ht-2c receptor antagonists Indoline derivatives useful as 5-ht-2c receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) C07D 213/72 (2006.01)

Patent

CA 2258559

The invention relates to heterocyclic compounds of formula (I) or a salt thereof wherein R1 is hydrogen or C1-6 alkyl; R2, R3 and R4 groups are independently hydrogen, halogen or C1-6 alkyl optionally substituted by one or more fluorine atoms, having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders such as anxiety.

L'invention concerne des composés hétérocycliques de formule (I), dans laquelle R<1> est hydrogène ou alkyle C1-C6, et les groupes R<2>, R<3> et R<4> sont indépendamment hydrogène, halogène ou alkyle C1-C6 éventuellement substitués par un ou plusieurs atomes de fluor, et leurs sels, ces composés ayant une activité pharmacologique. L'invention concerne également des procédés permettant de les préparer et des compositions les contenant, ainsi que leur utilisation dans le traitement des troubles du système nerveux central tels que l'angoisse.

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