C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 209/34 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2498781
The invention relates to heterocyclically substituted indolinones of general formula (I), in which R1 to R5 and X are defined as cited in claim 1, to their tautomers, diastereomers, enantiomers and to their mixtures, prodrugs and salts, in particular their physiologically compatible salts. Said compounds exhibit valuable pharmacological characteristics, in particular an inhibiting action on various receptor tyrosine kinases and cyclin-CDK complexes and on the proliferation of endothelial cells and various tumour cells. The invention also relates to medicaments containing said compounds, to the use of the latter and to a method for producing the same.
L'invention concerne des indolinones à susbtitution hétérocyclique de formule générale (I), dans laquelle : R¿1? à R¿5? et X sont tels que définis dans la première revendication. Cette invention concerne également leurs tautomères, diastéréoisomères, énantiomères, mélanges, promédicaments ainsi que leurs sels, en particulier leurs sels physiologiquement acceptables. Ces composés présentent des propriétés pharmacologiques précieuses et, en particulier, exercent une action inhibitrice sur différents récepteurs tyrosine-kinase et complexes cycline/CDK ainsi que sur la prolifération de cellules endothéliales et de différentes cellules tumorales. La présente invention se rapporte en outre à des médicaments contenant ces composés, à leur utilisation ainsi qu'à leurs procédés de production.
Heckel Armin
Hilberg Frank
Kley Joerg
Lehmann-Lintz Thorsten
Lotz Ralf R. H.
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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