Indolizine compounds

A - Human Necessities – 61 – K

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Details

A61K 31/44 (2006.01) C07D 401/02 (2006.01) C07D 451/02 (2006.01) C07D 451/06 (2006.01)

Patent

CA 2509214

This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention also relates to pharmaceutical compositions comprising at least one compound of Formula (I) and methods for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines.

L'invention concerne des composés représentés par la formule (I), dans laquelle le noyau A, X, Y, Z, R¿1?, R¿2? et R¿3? sont tels que définis dans la demande. Ces composés sont utiles pour traiter et prévenir le cancer, des troubles inflammatoires, des maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. L'invention concerne aussi des compositions pharmaceutiques comprenant au moins un composé représenté par la formule (I), et des méthodes de traitement et de prévention du cancer, de troubles inflammatoires, de maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines.

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