Indolizine derivatives and process for preparing the same

Details Indolizine derivatives and process for preparing the same Indolizine derivatives and process for preparing the same

C - Chemistry, Metallurgy

07

D

260/272.5

C07D 471/04 (2006.01)

Patent

CA 1152077

ABSTRACT OF THE DISCLOSURE: Novel indolizine derivatives represented by the general formula : Image and the pharmaceutically acceptable acid addition salts thereof, wherein : R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups, X1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy, A represents a group selected from : R2= Image and R3 = Image in which X2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X3 represents hydrogen, chlorine, bromine, iodine or methyl, R1 represents a methyl, ethyl, n-propyl or n-butyl radical, n represents an integer in the range of 2 to 6 inclusine, with the proviso that when both X2 and X3 represent hydrogen or methyl, X1 is other than hydrogen. They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrthythmias.

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