Indolizine derivatives and process for preparing the same

Details Indolizine derivatives and process for preparing the same Indolizine derivatives and process for preparing the same

C - Chemistry, Metallurgy

07

D

260/246.1, 260/2

C07D 471/04 (2006.01) C07D 213/20 (2006.01)

Patent

CA 1071198

ABSTRACT OF THE DISCLOSURE Novel indolizine derivatives of the general formula: Image and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl- phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R1 and R2, which are different represent a hydrogen atom or a group of the formula: Image wherein R3 and R4, which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino or morpholino group and n is an integer in the range of from 2 to 6 inclusive. They are effective for treating certain pathological or otherwise abnormal conditions of the heart and more particularly sinus tachycardia. Certain of them are also useful in the treatment of angina pectoris and cardiac arrhythmia.

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