Indolizine inhibitors of leukotriene production

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2735521

The present invention relates to compounds of formula I and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

La présente invention concerne des composés de formule I et un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle les X1 à X4, R1 à R4, A, B, D et m sont tels que définis ici. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes dutilisation de ces composés dans le traitement de maladies et troubles divers, des procédés de préparation de ces composés et des intermédiaires utiles dans ces procédés.

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