C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/06 (2006.01) A61K 31/55 (2006.01) A61P 9/12 (2006.01) C07D 209/00 (2006.01) C07D 223/00 (2006.01)
Patent
CA 2375268
The invention is directed to tricyclic indoloazepine compounds useful as vasopressin receptor antagonists, pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions involving increased vascular resistance and cardiac insufficiency which include hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, Cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis or water retention in a subject in need thereof.
L'invention concerne des composés d'indoloazépine tricycliques utilisés comme antagonistes du récepteur de la vasopressine, des compositions pharmaceutiques comprenant lesdits composés, et des techniques de traitement d'états impliquant des résistances vasculaires accrues et une insuffisance cardiaque, notamment l'hypertension, l'insuffisance cardiaque congestive, l'insuffisance cardiaque, le vasospasme coronaire, l'ischémie cardiaque, la cirrhose du foie, le vasospame rénal, l'insuffisance rénale, l'ischémie et l'oedème cérébral, l'attaque, la thrombose ou la rétention d'eau.
Greco Michael N.
Hecker Leonard R.
Hoekstra William J.
Maryanoff Bruce
Matthews Jay M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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