Indolopyrrolocarbazole derivatives

Details Indolopyrrolocarbazole derivatives Indolopyrrolocarbazole derivatives

C - Chemistry, Metallurgy

07

H

C07H 5/06 (2006.01) A61K 31/70 (2006.01) C07H 19/044 (2006.01)

Patent

CA 2083534

A compound represented by the following general formula and a pharmaceutically acceptable salt thereof (see formula I) wherein R1 and R2 each independently represent a hydro- gen atom, lower alkyl group, lower alkenyl group, lower alkynyl group, aryl group, aralkyl group or heterocyclic group (the alkyl group, lower alkenyl group, lower alkynyl group, aryl group, aralkyl group and heterocyclic group may each have 1 to 5 substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo groups, amino groups, cyano groups, mono-lower alkylamino groups, di-lower alkylamino groups, hydroxyl groups and halogen atoms), or a group of the formula -Y-R3, and therein Y represents a carbonyl group, thio- carbonyl group or sulfonyl group, and R3 represents a hydrogen atom, lower alkyl group, cycloalkyl group, cycloalkylalkyl group, aryl group, aralkyl group, lower alkoxy group, hydrazino group, amino group, arylamino group, carbamoyl group or heterocyclic group (the lower alkyl group, cycloalkyl group, cycloalkylalkyl group, aryl group, aralkyl group and heterocyclic group may each have 1 to 4 substituents selected from the group consisting of halogen atoms, optionally protected hydroxyl groups, amino groups, carboxyl groups, carbamoyl groups, cyano groups, allyl groups and lower alkoxycarbonyl groups, and the amino group and carbamoyl group may each be mono- or di-substituted by lower alkyl group(s) optionally substi- tuted by substituent(s) selected from the group consist- ing of halogen atoms, hydroxyl groups, amino groups, carboxyl groups, carbamoyl groups and lower alkoxycar- bonyl groups); or R1 and R2 combine to represent a lower alkyli- dene group (the lower alkylidene group may have 1 to 4 substituents selected from the group consisting of amino groups, mono-lower alkylamino groups, di-lower alkylamino groups, hydroxyl groups, carboxyl groups and sulfonyl groups); or R1 and R2 combine together with the nitrogen atom to which they bind to form a heterocyclic group (the heterocyclic group may have on the ring lower alkyl group(s) optionally substituted by group(s) selected from the group consisting of amino groups, hydroxyl groups, carboxyl groups and sulfo group), G represents a pentose group or hexose group, and X1 and X2 each independently represent a hydro- gen atom, halogen atom, amino group, mono-lower alkyl- amino group, di-lower alkylamino group, hydroxyl group, lower alkoxy group, aralkoxy group, carboxyl group, lower alkoxycarbonyl group or lower alkyl group. This compound has an excellent antitumor effect.

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