Indolyl group containing compounds and the use thereof to...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/04 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/25 (2006.01) A61K 38/30 (2006.01) C07D 209/20 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176140

The present invention is directed to certain compounds of general structural formula (I), wherein R1, R1a, R3, R3a, R4, R5, R6, A, W, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

La présente invention concerne certains composés de la formule structurelle générale (I), dans laquelle R¿1?, R¿1a?, R¿3?, R¿3a?, R¿4?, R¿5?, R¿6?, A, W et n ont la notation ci-définie. Ces composés favorisent la libération d'hormones de croissance chez l'homme et l'animal. Cette propriété peut être exploitée chez les animaux d'élevage pour favoriser leur croissance, afin d'augmenter leur rendement en produits alimentaires à base de viande, et chez l'homme pour traiter les états physiologiques ou pathologiques caractérisés par une carence de la sécrétion d'hormone de croissance, par exemple en cas de petite taille chez les enfants présentant un déficit en hormone de croissance, et pour traiter les états pathologiques qui sont améliorés par les effets anabolisants de l'hormone de croissance. Des compositions pour la libération d'hormones de croissance dans lesquelles ces composés forment le principe actif sont également décrites.

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