Indolyl-pyridone derivatives having checkpoint kinase 1...

Details Indolyl-pyridone derivatives having checkpoint kinase 1... Indolyl-pyridone derivatives having checkpoint kinase 1...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4412 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2712959

Compounds of formula (I) have checkpoint kinase 1 (CHK1 ) inhibitory activity: wherein R1, R2, R5 and R6 are inde-pendently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, trifluoromethoxy, methylamino and dimethylamino; R3, and R4 are independently selected from hydrogen, hydroxy, C1-C3 alkyl, fluoro-(C1-C3)-alkyl, hydroxy-(C1C3)--alkyl, C1-C3 alkoxy, fluoro- (C1-C3)-alkoxy, hydroxy-(C1-C3)-alkoxy, -N(R11)-R12, -AIk-N(R11)-R12, -0-AIk- N(R11)-R12, -C(=O)OH, carboxy-(C1-C3)-alkyl, or -C(=O)-NH-R13; AIk is a straight or branched chain divalent C1-C6 alkylene radical; R7 and R8 are in-dependently selected from hydrogen, hydroxy, or C1-C3 alkoxy; X is a straight chain divalent C1-C3 alkylene radical, optionally substituted on one or more carbons by R9 and/or R10; W is selected from -C(=O)- N(-R16)- or -N(-R17)-C(=O)-; Y is hydrogen, C1-C3 alkyl, C1-C3 alkoxy, or halo; and Q is selected from optionally substituted phenyl, optionally substituted cyclohexyl, or an optionally substituted 6-membered monocyclic heteroaryl ring.

Cette invention concerne des composés de formule (I) ayant une activité d'inhibition de la protéine checkpoint kinase 1 (CHK1). Dans la formule (I) selon l'invention, R1, R2, R5 et R6 sont indépendamment choisis parmi un atome d'hydrogène, un groupe hydroxy, méthyle, trifluorométhyle, hydroxyméthyle, méthoxy, trifluorométhoxy, méthylamino et diméthylamino; R3, et R4 sont indépendamment choisis parmi un atome d'hydrogène, un groupe hydroxy, alkyle C1-C3, fluoroalkyle C1-C3, hydroxyalkyle C1C3, alcoxy C1-C3, fluoroalcoxy C1-C3, hydroxyalcoxy C1-C3, -N(R11)-R12, -Alk-N(R11)-R12, -O-Alk-N(R11)-R12, -C(=O)OH, carboxyalkyle C1-C3, ou -C(=O)-NH-R13; Alk est un radical alkylène C1-C6 divalent à chaîne droite ou ramifiée; R7 et R8 sont indépendamment choisis parmi un atome d'hydrogène, un groupe hydroxy, ou alcoxy C1-C3; X est un radical alkylène C1-C3 divalent à chaîne droite, éventuellement substitué sur un ou plusieurs carbones par R9 et/ou R10 ; W est choisi parmi -C(=O)-N(-R16)- ou -N(-R17)-C(=O)-; Y est un atome d'hydrogène, un groupe alkyle C1-C3, alcoxy C1-C3, ou halogéno; et Q est choisi parmi un groupe phényle éventuellement substitué, cyclohexyle éventuellement substitué, ou un cycle hétéroaryle monocyclique de 6 chaînons éventuellement substitué.

Affiliated with

Also associated with

Rating

Indolyl-pyridone derivatives having checkpoint kinase 1... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indolyl-pyridone derivatives having checkpoint kinase 1..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indolyl-pyridone derivatives having checkpoint kinase 1... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1577056