Indolylmaleimide derivatives

Details Indolylmaleimide derivatives Indolylmaleimide derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/404 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2477774

Provided are compounds of Formula (I), which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infraction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of (I) are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders or autoimmune diseases e.g. rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, Hashimoto~s thyroidis, multiple sclerosis, myasthenia gravis, diabetes type I or II and the disorders associated therewith, e.g. angiopathy, diabetic proliferative retinopathy, diabetic macular edema, nephropathy, neuropathy and dawn phenomenon, respiratory diseases such as asthma or inflammatory lung injury, inflammatory liver injury, inflammatory glomerular injury, cutaneous manifestations of immunologically-mediated disorders or illnesses, inflammatory and hyperproliferative skin diseases (such as psoriasis, atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis), inflammatory eye diseases, e.g. Sjoegren~s syndrome, keratoconjunctivitis or uveitis, inflammatory bowel disease, Crohn~s disease or ulcerative colitis.

L'invention concerne des composés représentés par la formule (I), qui possèdent d'intéressantes propriétés pharmacologiques.

Affiliated with

Also associated with

Rating

Indolylmaleimide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indolylmaleimide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indolylmaleimide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1884619