Indolylmaleimide derivatives as protein kinase c inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 403/14 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2428133

The invention provides indolylmaleimide derivatives of formula I (see formula I) The derivatives may be used to treat or prevent T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

L'invention porte sur des dérivés d'indolylmaléimide contenant un résidu phényle, naphtyle, tétrahydronaphtyle, quinazolinyle, quinolyle, isoquinolyle pyrimidinyle substitués, et présentant des propriétés pharmaceutiques intéressantes, par exemple dans le traitement et/ou la prophylaxie des maladies ou troubles inflammatoires chroniques ou aigus induits par les lymphocytes T, des maladies auto-immunes, des rejets de greffons ou des cancers.

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