Indolylpiperidine derivatives as antihistaminic and...

Details Indolylpiperidine derivatives as antihistaminic and... Indolylpiperidine derivatives as antihistaminic and...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2375985

Indolylpiperidine compounds of formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoyl or hydroxyalkylene group; A2 represents a single bond, an alkylene or alkenylene group; W represents a single bond or a phenylene or furanylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; R2 represents a hydrogen or halogen atom or an alkyl or alkoxy group; and R3 represents a carboxyl group or a tetrazolyl group. The present invention provides novel indolylpiperidine compounds having improved antihistamine and antiallergic activity.

L'invention concerne des composés d'indolylpipéridine de la formule (I) dans laquelle A?1¿ est un groupe alkylène, alkylèneoxy, alkylènethio, alcanoyle ou hydroxyalkylène; A?2¿ est une liaison simple, un groupe alkylène ou alcénylène; W est une liaison simple ou un groupe phénylène ou furanylène insubstitué ou substitué par un ou plusieurs atomes d'halogène, des groupes alcoxy et/ou des groupes alkyles; R?2¿ est un atome d'hydrogène ou d'halogène ou un groupe alkyle ou alcoxy; et R?3¿ est un groupe carboxyle ou un groupe tétrazolyle. Les nouveaux composés d'indolylpipéridine de l'invention possèdent une activité antihistaminique et antiallergique améliorée.

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