Inducement of thermotolerance with benzoquinonoid ansamycins

Details Inducement of thermotolerance with benzoquinonoid ansamycins Inducement of thermotolerance with benzoquinonoid ansamycins

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A01N 1/02 (2006.01) A61K 31/395 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2218523

Thermotolerant phenotypes are developed in cells, tissues, organs and organisms by the administration of benzoquinonoid ansamycins such as herbimycin A and any of various analogs. The general stress tolerance resulting from this inducement offers benefits in a variety of ways, including rendering surgical patients more able to withstand the rigors of surgery, prolonging the shelf life of organs excised from organ donors, and prolonging the viability of tissue-cultured cells and organs.

Des phénotypes thermotolérants sont développés dans des cellules, tissus, organes et organismes par l'administration d'ansamycines benzoquinonoïdes telles que l'herbimycine A et des analogues divers. La tolérance générale au stress résultant de cette induction offre divers avantages, notamment en rendant les patients opérés plus aptes à résister aux rigueurs de l'opération chirurgicale, en permettant de prolonger la durée de conservation d'organes prélevés sur des donneurs et en prolongeant la viabilité de cellules et d'organes soumis à la culture de tissus.

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