C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0786 (2010.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2307343
The present invention relates to the use of macrophages in the function of antigen presenting cells (APC) to redirect the balance of the CD4+ T helper 1(Th1)/CD4+ T helper 2(Th2) cell subsets during an immune response. More particularly, the present invention is directed to pharmaceutical formulations comprising macrophages or a cell population containing macrophages, optionally together with a suitable excipient, and methods for suppressing the Th2 dependent humoral immune response and/or to stimulate the Th1 dependent, cellular immune response.
L'invention concerne l'utilisation de macrophages dans la fonction de cellules présentant l'antigène (APC) de manière à redistribuer le rapport de sous-ensembles de lymphocytes T auxiliaires à CD4<+> de type 1 (Th1)/lymphocytes T auxiliaires à CD4<+> de type 2 (Th2) pendant une réaction immune. Plus particulièrement, cette invention a pour objet des formulations pharmaceutiques comprenant des macrophages ou une population de cellules contenant des macrophages, éventuellement associées à un excipient approprié, ainsi que des procédés pour supprimer la réaction immunitaire humorale dépendante de Th2 et/ou pour stimuler la réaction immunitaire cellulaire dépendante de Th1.
Desmedt Marjory
Fiers Walter
Grooten Johan
Fetherstonhaugh & Co.
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw
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