Inducible gene expression

Details Inducible gene expression Inducible gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2575480

The invention relates to vector constructs for an HIV-specific gene therapy. The expression of transgenes is coupled with an infection of the cell with HIV while the transcription of the transgene is controlled by a transcription control region derived from HIV. In addition, the transgene is improved with regard to RNA stability and expression efficiency by modifying the nucleotide sequence.

L'invention concerne des produits de synthèse vectoriels pour une thérapie génique spécifique du VIH. L'expression des transgènes est couplée à une infection de la cellule par le VIH, du fait que la transcription du transgène est régulée par une région de contrôle de transcription dérivée du VIH. Le transgène est en outre amélioré par modification de la séquence de nucléotides, en termes de stabilité de l'ARN et d'efficacité de l'expression.

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