C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/433 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 31/5355 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2589433
The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, V, X, and Y are independently selected from the group consisting of CR4 and N; Z is from the group consisting of CR3 and N; W and W.prime. are independently selected from the group consisting of CH2, CR 7R8, NR9, O, N(O), S(O)q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
L'invention concerne des composés et des méthodes utiles comme inhibiteurs de l'oxyde nitrique synthase. Certains composés selon l'invention comprennent la formule structurelle suivante : (I) dans laquelle T, X et Y sont choisis indépendamment dans le groupe constitué de CR4, N, NW, S et O ; U est choisi dans le groupe constitué de CR10 et N ; V est choisi dans le groupe constitué de CR4 et N; W et W' sont indépendamment choisi dans le groupe constitué de CH2, CR7R8, NR9, O, N(O), S(O)q et C(O) ; n, m et p valent indépendamment un entier de 0 à 5 ; q vaut 0, 1 ou 2 ; et d'autres substituants sont tels que définis dans le descriptif. D'autres composés selon l'invention présentent des formules structurelles telles que définies dans le descriptif. L'invention concerne également des compositions pharmaceutiques comprenant les composés selon l'invention.
Chen Xiaohong
Cousins Russell D.
Gahman Timothy C.
Hassig Christian A.
Herbert Mark R.
Kalypsys Inc.
Mcfadden Fincham
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