C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61F 2/06 (2006.01) A61K 31/70 (2006.01) A61K 35/34 (2006.01) A61K 48/00 (2006.01) C12N 9/02 (2006.01) C12N 9/06 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2193827
The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed invention, iNOS-directed gene therapy involves specific targeting of a DNA sequence encoding a protein or protein fragment with iNOS biological activity for treating vascular diseases and disorders, antitumor applications and in response to certain microbial infections.
L'invention concerne un clone complet d'ADNc d'iNOS hépatocytaire humain et différentes applications de thérapie génique utilisant une séquence d'ADN d'iNOS. Dans les modes de réalisation préférés de l'invention, la thérapie génique dirigée contre iNOS consiste à cibler une séquence d'ADN codant une protéine ou un fragment de protéine présentant une activité biologique d'iNOS pour traiter les maladies et troubles vasculaires, pour des applications antitumorales et dans la réponse à certaines infections microbiennes.
Billiar Timothy R.
Geller David A.
Nussler Andreas K.
Simmons Richard L.
Tzeng Edith
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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