A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07K 14/435 (2006.01) C07K 14/525 (2006.01) C07K 14/545 (2006.01) C07K 14/57 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2170236
A novel method for utilizing the immune apparatus to re-move and/or down-regulate self-proteins consists in inserting one or more foreign T-cell epitopes in such proteins by molecular bio-logical means, thereby rendering said proteins immunogenic. The modulated self-proteins can be used as autovaccines against undesir-able proteins in humans or animals, said autovaccine being useful as vaccines against a number of diseases, e.g. cancer, chronic inflam-matory diseases, rheumatoid arthritis, inflammatory bowel diseases, allergic symptoms or diabetes mellitus.
Nouveau procédé d'utilisation du système immunitaire dans l'élimination et/ou la rétro-régulation des protéines endogènes. Le procédé consiste à insérer par voie biologique moléculaire dans ces protéines un ou plusieurs épitopes de lymphocytes T exogènes, lesdites protéines étant ainsi rendues immunogènes. Les protéines endogènes modulées peuvent servir d'autovaccins dirigés contre des protéines indésirables chez l'animal ou chez l'homme, ces autovaccins étant utilisables comme vaccins dirigés contre un certain nombre de maladies telles que le cancer, les maladies inflammatoires chroniques, la polyarthrite rhumatoïde, les maladies intestinales inflammatoires, les symptômes allergiques ou le diabète sucré.
Elsner Henrik
Mouritsen Sýren
Bn Immunotherapeutics Inc.
Mouritsen & Elsner A/s
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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