Inducing resistance to tumor growth with soluble igf-1 receptor

Details Inducing resistance to tumor growth with soluble igf-1 receptor Inducing resistance to tumor growth with soluble igf-1 receptor

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 31/70 (2006.01) A61K 38/30 (2006.01) A61K 48/00 (2006.01) C07K 14/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235695

Individuals having tumors are treated with pharmaceutical compositions comprising expression vectors, preferably adenovirus or retroviruses, comprising nucleic acid molecules encoding soluble IGF-1R. Such vectors express soluble IGF-1R in tumor cells resulting in reversal of the transformed phenotype, induction of apoptosis, and inhibition of tumorigenesis.

Selon l'invention, les sujets présentant des tumeurs sont traités avec des compositions pharmaceutiques contenant des vecteurs d'expression, de préférence des adénovirus ou des rétrovirus, comportant des molécules d'acide nucléique codant le IGF-1R soluble. Ces vecteurs expriment, dans les cellules tumorales, le IGF-1R soluble qui entraîne une inversion du phénotype transformé, provoque l'apoptose et inhibe l'oncogenèse.

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