A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4709 (2006.01) A61K 31/4402 (2006.01) C40B 30/02 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2681481
The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby incuding cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject.
La présente invention concerne un procédé consistant à induire des cellules cancéreuses en dormance et à traiter un cancer chez un sujet. Ce procédé implique l'administration à un sujet d'une quantité efficace d'un composé qui rompt l'interaction entre le récepteur d'activateur de plasminogène d'urokinase et l'intégrine, amenant ainsi les cellules cancéreuses en dormance et traitant le cancer chez les sujets. Il est également révélé un procédé de rupture de l'interaction entre l'intégrine et le récepteur d'activateur de plasminogène d'urokinase sur des cellules cancéreuses. La présente invention concerne également un procédé de criblage de composés efficace pour induire une dormance de tumeur et traiter un cancer chez un sujet.
Aguirre-Ghiso Julio A.
Chaurasia Pratima
Ossowski Liliana
Ploug Michael
Zhou Ming-Ming
Gowling Lafleur Henderson Llp
Mount Sinai School Of Medicine
Rigshospitalet
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