Induction of a th1-like response in vitro

Details Induction of a th1-like response in vitro Induction of a th1-like response in vitro

G - Physics

01

N

G01N 33/50 (2006.01) C07K 14/025 (2006.01) C07K 14/35 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2378097

The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.

L'invention concerne des compositions et des procédés permettant de stimuler une réponse de type Th-1 in vitro. Ces compositions englobent les protéines de fusion et les conjugués qui renferment au moins une partie de protéine de choc thermique. On peut induire la réponse considérée par contact in vitro entre un échantillon de cellule renfermant des lymphocytes naïfs et une protéine de fusion ou un conjugué du type décrit dans l'invention. Il est possible de déceler cette réponse en mesurant l'interféron gamma produit par l'échantillon.

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