A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C12N 5/0786 (2010.01) A61K 31/34 (2006.01) A61K 31/423 (2006.01) A61K 31/5415 (2006.01) A61K 31/553 (2006.01) A61K 31/7048 (2006.01) A61K 35/14 (2006.01) A61K 35/76 (2006.01) A61K 38/13 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2295229
The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. The agent may consist of a calcium ionophore, a calcium export blocking agent, a calcineurin pathway activating agent etc. Methods of obtaining the monocytes are also disclosed. In addition, the present invention relates to methods of inducing bone marrow progenitor cells and endothelial cells to express molecules involved in generating immune responses. Methods of modulating the expression of molecules involved in generating immune responses are also disclosed, as are methods of treating cancer and leukemia.
L'invention concerne des procédés d'augmentation de la capacité de présentation de l'antigène de monocytes par la mise en contact de ces derniers avec un agent qui augmente le taux de calcium intracellulaire. Des procédés d'obtention de monocytes sont également décrits. De plus, l'invention se rapporte à des procédés induisant l'expression par des cellules parentes de la moelle osseuse et des cellules endothéliales, de molécules impliquées dans la génération de réponses immunitaires. Elle porte encore sur des procédés de modulation de l'expression de molécules impliquées dans la génération de réactions immunitaires, tels que des procédés de traitement du cancer et de la leucémie.
Carter Charles
Cohen Peter A.
Czerniecki Brian J.
Koski Gary K.
Ojeifo John O.
Sim & Mcburney
The Government Of The United States Of America As Represented By Department Of Health And Human Services
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