C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/16 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61P 31/14 (2006.01) C07K 14/005 (2006.01) C07K 16/10 (2006.01) C12N 15/49 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2548483
The invention relates to immunogenic constructs that in principle comprise two different domains of the transmembrane envelope protein of enveloped viruses including retroviruses including HIV, a pharmaceutical agent for inducing humoral neutralizing immune responses to viral infections and to a kit for the detection of antibodies and viral antigens. The invention also relates to a method for inducing an antibody response and to a method for the passive immunization of an organism using neutralizing antibodies that were obtained using the above-mentioned immunogenic constructs. Finally, the invention relates to a bioassay for detecting viral infection and for detecting the production of neutralizing antibodies.
La présente invention concerne des constructions immunogènes qui renferment principalement deux zones différentes de la protéine transmembranaire de virus enveloppés, y compris les rétrovirus et le VIH, ainsi qu'un agent pharmaceutique conçu pour l'induction de réponses immunitaires neutralisantes humorales contre des infections virales et une trousse pour identifier des anticorps et des antigènes viraux. La présente invention concerne également un procédé pour induire une réponse d'anticorps et un procédé pour immuniser un organisme de manière passive, en utilisant des anticorps neutralisants qui sont obtenus avec lesdites constructions immunogènes, ainsi qu'un essai biologique pour identifier l'infection à virus et pour identifier la formation d'anticorps neutralisants.
Denner Joachim
Fiebig Uwe
Karlas Alexander
Kurth Reinhardt
Schmolke Mirco
Deeth Williams Wall Llp
Letztvertreten Durch Den Praesidenten Des Robert-Koch-Institut Brd Vertreten Durch Das Bundesministerium Fuer Gesundheit Und So
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