A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2574176
Some types of cancer cells express one or more Toll-like receptors (TLRs). These TLRs are therapeutic targets. The invention relates to methods for treating Toll-like receptor expressing cancers and tumor cells by selecting a TLR expressing tumor cell and contacting the cell with a therapeutically effective amount of a TLR ligand. The invention particularly relates to methods for treating TLR3 expressing cancers and tumor cells using TLR3 agonists.
Certains types de cellules cancéreuses expriment un ou plusieurs récepteurs Toll-like (TLR). Ces TLR constituent des cibles thérapeutiques. L'invention concerne des méthodes de traitement de cancers et de cellules tumorales exprimant des récepteurs Toll-like, qui consistent à sélectionner une cellule tumorale exprimant TLR et à mettre celle-ci en contact avec une quantité thérapeutiquement efficace d'un ligand de TLR. L'invention concerne en particulier des procédés utilisant des agonistes de TLR3 pour traiter des cancers et des cellules tumorales exprimant des récepteurs TLR3.
Coste-Invernizzi Isabelle
Lebecque Serge
Renno Toufic
Rissoan Marie-Clotilde
Salaun Bruno
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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