Induction of apoptosis via arts-iap complexes

Details Induction of apoptosis via arts-iap complexes Induction of apoptosis via arts-iap complexes

G - Physics

01

N

G01N 33/53 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2552955

The present invention provides complexes containing an ARTS protein and an IAP protein, compounds that disrupt same, and use of the compounds in treating neuro-degenerative disease, ischemic injury, myelodysplasia, atherosclerosis, various auto-immune diseases, cytopenia, pancreatitis, and periodonitis, and in decreasing susceptibility of a cell to apoptosis. The present invention also provides methods for identifying biologically active regions of ARTS protein, and use of mimetic compounds of same in treating apoptosis-related disorders, cancer, and other neoplastic diseases and disorders.

La présente invention a trait à des complexes contenant une protéine ARTS et une protéine IAP, des composés de disruption de telles complexes, et l'utilisation des composés dans le traitement de maladie neurodégénérative, la lésion ischémique, la myélodysplasie, l'athérosclérose, diverses maladies auto-immunes, la cytopénie, la pancréatite, et la desmodontite, et dans la réduction de la susceptibilité à l'apoptose cellulaire. La présente invention a également trait à des procédés pour l'identification de régions d'activité biologique de la protéine ARTS, et l'utilisation de composés mimétiques de celle-ci dans le traitement de troubles liés à l'apoptose, le cancer, et d'autres maladies et troubles néoplasiques.

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