Induction of cytotoxic t-lymphocyte responses

Details Induction of cytotoxic t-lymphocyte responses Induction of cytotoxic t-lymphocyte responses

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 39/015 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2204738

Methods and compositions useful for inducing a cytotoxic T-lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle- forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.

Techniques et compositions permettant d'obtenir des réactions lymphocytaires T cytotoxiques chez l'homme ou chez les animaux domestiques ou importants pour l'agriculture. La technique consiste à produire l'antigène auquel la réaction lymphocytaire est souhaitée et à définir la formulation d'un antigène comprenant notamment ou exclusivement deux détergents stabilisants ou davantage, un agent de formation de micelles et une huile. La formulation de cet antigène se caractérise de préférence par l'absence d'un composé peptidique immunostimulant, ou alors la concentration de ce composé est suffisamment faible pour ne pas réduire la réaction lymphocytaire T cytotoxique. Cette formulation se présente sous forme d'une émulsion aqueuse stable.

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