A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2434546
Mucosal delivery of antigens using, for example, a replication-defective gene delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local and/or systemic immune responses following mucosal immunization regimes.
L'invention concerne la distribution d'antigènes sur des muqueuses en utilisant, par exemple, un véhicule fournissant un gène défectif de réplication, en particulier, des vecteurs et particules d'alphavirus défectif de réplication. L'invention concerne en outre des compositions comprenant un adjuvant des muqueuses et un ou plusieurs antigènes dérivés de HIV. Enfin, l'invention concerne l'utilisation de véhicules fournissant ces gènes de façon à provoquer des réponses immunitaires des muqueuses, locales et/ou systémiques, à la suite de régimes d'immunisation des muqueuses.
Dubensky Thomas Jr.
O'hagan Derek
Polo John
Vajdy Michael
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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