A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 35/74 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2631598
The present invention relates to the induction of tolerance to antigens, by mucosal, preferably oral delivery of the antigen in combination with an immunomodulating compound producing micro-organism. More specifically, the invention relates to the induction of Foxp3+ and/or IL-10 and/or TGF-.beta. producing regulatory T-cells, capable of suppressing undesired immune responses toward an antigen, by oral delivery of said antigen in combination with an immunosuppressing cytokine secreting micro-organism.
La présente invention concerne l'induction d'une tolérance à des antigènes, par administration muqueuse, de préférence orale, à un antigène en combinaison avec un microorganisme produisant un composé immunomodulateur. Plus spécifiquement, l'invention concerne l'induction de lymphocytes T régulateurs produisant Foxp3+ et/ou IL-10 et/ou TGF-.beta., capable de supprimer des réponses immunitaires indésirables contre un antigène, par administration orale dudit antigène en combinaison avec un microorganisme sécrétant une cytokine immunosuppresseuse.
Rottiers Pieter
Snoeck Veerle
Actogenix Nv
Smart & Biggar
LandOfFree
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