Induction of p53 expression by neutralization of...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2735169

The present invention relates to the use of anti-human neuropilin-2 antibodies, or of ligands of human neuropilin-2 derived from these antibodies, for obtaining a medicament for increasing p53 expression and for inducing tumour cell apoptosis in the context of an anticancer treatment.

La présente invention est relative à l'utilisation d'anticorps anti- neuropiline 2 humaine, ou des ligands de la neuropiline 2 humaine dérivés de ces anticorps, pour l'obtention d'un médicament destiné à augmenter l'expression de p53 et à induire l'apoptose des cellules tumorales dans le cadre d'un traitement anticancéreux.

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