Induction of programmed cell death by n5 gene

Details Induction of programmed cell death by n5 gene Induction of programmed cell death by n5 gene

A - Human Necessities

61

K

A61K 39/245 (2006.01) A61K 39/21 (2006.01) A61K 39/235 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2382952

The present invention concerns methods and compositions for treating cancer in a subject. These methods and compositions utilize the activities associated with the N5 gene product, p84N5. p84N5 contains a functional death domain, can interact with the retinoblastoma gene product and is normally localized to the nucleus of cells. Increasing the activity level of p84N5 in cancer cells is beneficial for the treatment of cancer.

L'invention porte sur des procédés et compositions traitement du cancer utilisant les activités associées au produit génique p84N5 du gène N5. Le p84N5 qui contient un domaine létal fonctionnel peut interagir avec le produit génique du rétinoblastome, et est normalement localisé dans le noyau de la cellule. L'accroissement du niveau d'activité de p84N5 dans les cellules cancéreuses s'avère bénéfique pour le traitement du cancer.

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