Induction of t cell tolerance using a soluble molecule that...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2260752

The invention provides a soluble molecule capable of binding to the human CD40 antigen and to at least the human CD86 antigen, said antigens being located on the surface of human lymphocytes, as well as vectors capable of producing the molecule and uses of the molecule in inducing T cell tolerance. Said molecule is in particular an antibody, which can be a trispecific diabody capable of binding to CD40 and to both CD80 and CD86, or a bispecific diabody capable of binding to human CD40 and to human CD86, or else a trispecific triabody capable of binding to CD40, CD80 and CD86.

L'invention concerne une molécule soluble pouvant se fixer sur l'antigène humain CD40 et au moins sur l'antigène humain CD86, ces antigènes étant situés sur la surface de lymphocytes humains, des vecteurs pouvant produire cette molécule ainsi que des utilisations de celle-ci pour induire une tolérance aux lymphocytes T. Cette molécule est notamment constituée par un anticorps, lequel peut être un dianticorps pouvant se fixer sur CD40 et à la fois sur CD80 et CD86, ou un dianticorps à double spécificité, pouvant se fixer sur CD40 et sur CD86 humains, ou encore un trianticorps à triple spécificité pouvant se fixer sur CD40, CD80 et CD86.

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