Induction of tolerance to a therapeutic polypeptide

Details Induction of tolerance to a therapeutic polypeptide Induction of tolerance to a therapeutic polypeptide

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2411186

Liver-directed gene transfer can induce immunological tolerance to a polypeptide associated with the expression of a therapeutic nucleic acid Hepatic expression of a transgene induces tolerance to the expression product of the transgene, or to post-translational product related to transgene expression, thereby ameliorating or eliminating the immune responses associated with gene therapy and protein replacement, respectively, independent of the genetic background of the subject.

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