A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2440610
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.
L'invention concerne des variantes d'antigène comprenant des déterminants antigéniques de protéine de fixation à folate sous forme de composition jouant un rôle dans l'immunité contre une tumeur chez un individu. Cette variante sert à induire efficacement des lymphocytes T cytotoxiques, mais, de préférence, pas au point qu'ils deviennent sensibles à la mise sous silence par élimination, par exemple, par apoptose ou anergie par manque de réactivité.
Ioannides Constantin G.
Peoples George E.
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
Henry M. Jackson Foundation For The Advancement Of Military Medi In C.
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