Induction of tumor immunity by variants of folate binding...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2440610

The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.

L'invention concerne des variantes d'antigène comprenant des déterminants antigéniques de protéine de fixation à folate sous forme de composition jouant un rôle dans l'immunité contre une tumeur chez un individu. Cette variante sert à induire efficacement des lymphocytes T cytotoxiques, mais, de préférence, pas au point qu'ils deviennent sensibles à la mise sous silence par élimination, par exemple, par apoptose ou anergie par manque de réactivité.

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