Infectious bovine rhinotracheitis virus mutants, vaccines...

Details Infectious bovine rhinotracheitis virus mutants, vaccines... Infectious bovine rhinotracheitis virus mutants, vaccines...

C - Chemistry, Metallurgy

12

N

167/133, 195/1.2

C12N 7/01 (2006.01) A61K 39/265 (2006.01) C07K 14/06 (2006.01) C12N 15/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1299121

92 INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS MUTANTS, VACCINES CONTAINING SAME, METHODS FOR THE PRODUCTION OF SAME AND METHODS FOR THE USE OF SAME ABSTRACT Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.

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