Infectious bronchitis vaccines derived from ib-qx-like strains

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 7/08 (2006.01) A61K 39/215 (2006.01)

Patent

CA 2732822

The present invention relates to infectious bronchitis (IB) viruses derived from a recently identified genotype of IB virus known as IB-QX, or from viruses that are genetically related to IB-QX, herein referred to as IB-QX-like viruses. The IB viruses of the invention may be live and attenuated or inactivated. Live, attenuated IB viruses of the invention may be produced by serial passaging of an IB-QX-like virus. The IB viruses of the invention are useful for, inter alia, vaccines against IB-QX and IB-QX-like viruses. Heretofore, known vaccine strains of IB viruses have proven insufficient to protect against infectious bronchitis caused by IB-QX and IB-QX-like viruses.

La présente invention concerne des virus de bronchite infectieuse (IB) dérivés dun génotype récemment identifié de virus IB appelé IB-QX, ou de virus qui sont génétiquement apparentés à IB-QX, présentement appelés virus de type IB-QX. Les virus IB de linvention peuvent être vivants et atténués ou inactivés. Les virus IB vivants, atténués de linvention peuvent être produits par passage en série dun virus de type IB-QX. Les virus IB de linvention sont utiles pour, entre autres, des vaccins contre des virus IB-QX et de type IB-QX. À ce jour, des souches de vaccin de virus IB connues se sont avérées insuffisantes pour protéger contre une bronchite infectieuse causée par des virus IB-QX et de type IB-QX.

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