Inferring gene regulatory networks from time-ordered gene...

G - Physics – 06 – F

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G06F 17/18 (2006.01) G01N 33/48 (2006.01) G06F 17/13 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2504856

Embodiments of methods are provided that can be used to estimate network relationships between genes of an organism using time course expression data and a set of linear differential equations. Aikaike's Information Criterion and mask tools can be used to reduce the number of elements in a matrix by determining which elements are zero or not significantly changed under the conditions of the study. Maximum likelihood estimation and new statistical methods are used to evaluate the significance of a proposed network relationship.

Des modes de réalisation de l'invention concernent des procédés pouvant être utilisés pour estimer des relations de réseau entre des gènes d'un organisme, au moyen de données d'expression chronologiques, et d'un ensemble d'équations différentielles linéaires. Le critère d'information Akaike, et des outils de masque peuvent être utilisés pour réduire le nombre d'éléments d'une matrice, par la détermination des éléments qui ne subissent aucun changement ou qui ne subissent presque pas de changement significatif, dans les conditions de l'étude. Une estimation de probabilité maximale et de nouveaux procédés statistiques sont utilisés pour évaluer l'importance d'une relation de réseau proposée.

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