Inflammation and oxidative stress level assay

Details Inflammation and oxidative stress level assay Inflammation and oxidative stress level assay

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/74 (2006.01) G01N 33/88 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2688506

The present invention relates to a method for determining the systemic metabolic status of an organism in relation to inflammation and oxidative stress using a biological sample (Inflammation and Oxidative Stress Level Assay). This comprises detection and quantification of one or more derivatives of arachidonic acid (eicosanoids), linoleic acid and/ or docosahexaenoic acid, preferably together with one or more oxidative stress parameters and/or with one or more analytes from other metabolite classes in parallel, as well as a kit adapted for carrying out such a method. Moreover, the invention relates to the biomarkers as employed in the method.

La présente invention concerne un procédé permettant de déterminer le statut métabolique systémique d'un organisme associé à une inflammation et à un stress oxydatif au moyen d'un échantillon biologique (dosage du niveau d'inflammation et de stress oxydatif). Ce procédé consiste à détecter et à quantifier un ou plusieurs dérivés de l'acide arachidonique (éicosanoïdes), de l'acide linoléique et/ou de l'acide docosahexaènoïque et, parallèlement, de préférence un ou plusieurs paramètres de stress oxydatif et/ou un ou plusieurs analytes appartenant à d'autres classes de métabolites. Un kit adapté pour mettre en AEuvre ce procédé est également proposé. De plus, l'invention concerne les biomarqueurs utilisés dans le procédé.

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