Inflammatory bowel disease first step assay system

Details Inflammatory bowel disease first step assay system Inflammatory bowel disease first step assay system

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2331447

The present invention provides a highly sensitive method of diagnosing inflammatory bowel disease (IBD) in an individual. The method includes the steps of isolating a sample from the individual; determining by non-histological means whether the sample is positive for anti-neutrophil cytoplasmic antibodies (ANCA); determining whether the sample is positive for anti-Saccharomyces cerevisiae immunoglobulin A (ASCA-IgA); determining whether the sample is positive for anti-Saccharomyces cerevisiae immunoglobulin G (ASCA-IgG); and diagnosing the individual as having IBD when the sample is positive for ANCA, ASCA-IgA or ASCA-IgG, and diagnosing the individual as not having IBD when the sample is negative for ANCA, ASCA-IgA and ASCA-IgG, provided that the method does not include histological analysis of neutrophils.

La présente invention concerne un procédé hautement sensible de diagnostic d'une maladie intestinale inflammatoire chez un individu. Ce procédé consiste à prélever sur l'individu un échantillon, puis à déterminer par des voies non histologiques si l'échantillon est positif aux anticorps cytoplasmiques anti-neutrophiles (ANCA). Le procédé consiste ensuite à déterminer si l'échantillon est positif à l'immunoglobuline A anti-Saccharomyces cerevisiae (ASCA-IgA), puis à déterminer si l'échantillon est positif à l'immunoglobuline G anti-Saccharomyces cerevisiae G (ASCA-IgG). Le procédé consiste alors à établir le diagnostic que l'individu souffre d'une maladie intestinale inflammatoire dès lors que l'échantillon est positif à l'ANCA, à l'ASCA-IgA ou à l'ASCA-IgG, et à établir le diagnostic que l'individu ne souffre pas de maladie intestinale inflammatoire dès lors que l'échantillon est négatif à l'ANCA, à l'ASCA-IgA et à l'ASCA-IgG, dans la mesure ou le procédé ne comporte pas d'analyse histologique des neutrophiles.

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