Inflammatory cytokine secretion inhibition

A - Human Necessities – 61 – K

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A61K 35/28 (2006.01) A61K 35/00 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2430937

A process of decreasing the expression of one or more of the inflammatory cytokines IFN-y and IL-6 from cells in a mammalian patient, comprises administering to the patient an effective amount of stressed mammalian blood cells, said stressed cells having been extracorporeally subjected to at least one stressor selected from oxidative stress and ultraviolet radiation. These findings are indicative of the use of the process in the treatment for alleviation of chronic fatigue syndrome.

L'invention concerne un procédé permettant de diminuer l'expression d'une ou de plusieurs cytokines IFN-.gamma. et IL-6 de cellules chez un patient mammifère, et qui consiste à administrer au patient une quantité pharmaceutiquement efficace de cellules sanguines mammifères stressées, ces cellules ayant été soumises de manière extra-corporelle à au moins un agresseur sélectionné parmi le stress oxydant et le rayonnement ultraviolet. Le procédé peut s'utiliser pour alléger le syndrome de fatigue chronique.

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