Influenza hemagglutinin compositions and uses thereof

Details Influenza hemagglutinin compositions and uses thereof Influenza hemagglutinin compositions and uses thereof

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2759873

The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and / or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and / or preventing influenza virus infection.

La présente invention a trait aux domaines de la médecine, de la santé publique, de l'immunologie, de la biologie moléculaire et de la virologie. L'invention concerne des compositions, des compositions vaccinales et des compositions pharmaceutiques permettant le traitement, l'apport d'améliorations et/ou la prévention de la grippe. Les compositions, compositions vaccinales et compositions pharmaceutiques de l'invention comprennent une particule analogue à un virus, d'un bactériophage à ARN, et au moins un antigène, ce dernier étant un ectodomaine d'une protéine d'hémagglutinine de virus grippal ou un fragment dudit ectodomaine de protéine d'hémagglutinine de virus grippal. Lorsqu'elles sont administrées à un animal, de préférence à un être humain, lesdites compositions, compositions vaccinales et compositions pharmaceutiques induisent des réponses immunitaires efficaces, en particulier des réponses anticorps, lesdites réponses anticorps étant généralement et de préférence dirigées contre le virus grippal. Ainsi, l'invention concerne également des procédés de traitement, d'apport d'améliorations et/ou de prévention de l'infection par un virus grippal.

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