Influenza inhibiting compositions and methods

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/11 (2006.01) A61K 38/00 (2006.01) A61K 39/145 (2006.01) A61K 39/42 (2006.01) A61P 31/16 (2006.01) A61P 37/04 (2006.01) C07K 16/10 (2006.01) C07K 17/02 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2691358

The present invention provides peptides, peptide analogs, peptide derivatives and pharmaceutical compositions useful for treating or preventing influenza infections or preventing the person-to-person transmission of an influenza infection. A peptide of the invention comprises an influenza virus-cell fusion inhibiting portion of the fusion initiation region (FIR) of a wild-type influenza hemagglutinin 2 protein or a variant thereof. In a preferred embodiment, a peptide of the invention consists of 8 to 40 con-secutive amino acid residues a portion of a wild-type influenza hemagglutinin 2 protein or a variant thereof, the portion of the protein comprising the FIR of the protein and up to five amino acid residues on the amino-terminal and carboxy-terminal sides of the FIR.

La présente invention concerne des peptides, des analogues de peptides, des dérivés de peptides et des compositions pharmaceutiques utiles pour le traitement ou la prévention d'infections grippales ou pour la prévention d'une transmission d'une personne à une autre d'une infection grippale. Un peptide de l'invention compose une partie inhibant la fusion cellulaire du virus de la grippe de la région initiant la fusion (FIR) d'une protéine d'hémagglutinine 2 de la grippe de type sauvage ou de l'un de ses variants. Dans un mode de réalisation préféré, un peptide de l'invention est constitué d'une partie de 8 à 40 résidus d'acides aminés consécutifs d'une protéine d'hémagglutinine 2 de la grippe de type sauvage ou de l'un de ses variants, la partie de la protéine comprenant la FIR de la protéine et jusqu'à cinq résidus d'acides aminés sur les côtés amino-terminal et carboxy-terminal de la FIR.

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