Influenza recombinant subunit vaccine

Details Influenza recombinant subunit vaccine Influenza recombinant subunit vaccine

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61P 31/16 (2006.01) C07K 14/11 (2006.01) C12N 7/04 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2656705

The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.

L'invention concerne des protéines de la grippe, y compris des protéines sous-unitaires et des compositions immunogènes pouvant être utilisées, avec ou sans adjuvants, comme vaccins antigrippaux dans des modèles animaux et chez l'homme. Les protéines recombinées sont exprimées à partir de cellules d'insectes transformées qui contiennent des copies intégrées des cassettes d'expression appropriées dans leur génome. L'invention utilise un système d'expression de Drosophila melanogaster pour produire de grandes quantités de protéines sous-unitaires recombinées dont la conformation est analogue à celle de la protéine native.

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