Influenza vaccine composition

Details Influenza vaccine composition Influenza vaccine composition

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2448208

An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilised in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may comprise a micelle modifying excipient, for example .alpha. tocopherol or a derivative thereof in a sufficient amount to stabilise the haemagglutinin.

L'invention concerne une préparation de virus de la grippe inactivée. Cette préparation contient un antigène d'hémagglutinine stabilisé en l'absence de thiomersal, ou à de faibles concentrations de thiomersal, et l'hémagglutinine peut être détectée par un test SRD. La préparation de virus de la grippe peut comprendre un excipient modifiant les micelles par exemple un .alpha.-tocophérol ou un dérivé de ce dernier selon une quantité suffisante pour stabiliser l'hémagglutinine.

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