Influenza vaccines containing hemagglutinin and matrix proteins

Details Influenza vaccines containing hemagglutinin and matrix proteins Influenza vaccines containing hemagglutinin and matrix proteins

A - Human Necessities

61

K

A61K 39/145 (2006.01)

Patent

CA 2640248

An immunogenic composition comprising influenza virus haemagglutinin and matrix proteins. These may be from influenza viruses grown in cell culture rather than eggs. The matrix protein may be a fragment of a full-length viral matrix protein e.g. a matrix M1 fragment with a molecular weight of less than 2OkDa. The composition may be a subunit vaccine comprising purified surface glycoproteins.

L'invention concerne une composition immunogène qui comprend des hémaglutinines et des protéines matricielles du virus de la grippe. Ces dernières peuvent être extraites de virus de la grippe issus de cultures cellulaires plutôt que d'oeufs. La protéine matricielle peut être un fragment d'une protéine matricielle virale de pleine longueur, p.ex. un fragment matriciel M1 d'un poids moléculaire inférieur à 20 kDa. La composition peut être un vaccin de sous-unités renfermant des glycoprotéines de surface purifiées.

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