Influenza virus-like particles (vlps) comprising hemagglutinin

Details Influenza virus-like particles (vlps) comprising hemagglutinin Influenza virus-like particles (vlps) comprising hemagglutinin

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A61K 35/76 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/44 (2006.01) C12P 21/02 (2006.01) A01H 5/00 (2006.01)

Patent

CA 2615372

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

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