Influenza virus vaccine

Details Influenza virus vaccine Influenza virus vaccine

A - Human Necessities

61

K

A61K 39/145 (2006.01) C12N 7/01 (2006.01) C12N 15/44 (2006.01)

Patent

CA 2649661

The invention relates to influenza virus vaccines, and in particular to a reassortant influenza virus which has at least its haemagglutinin gene derived from a non-pathogenic or low pathogenic influenza virus, and its other genes derived from a donor strain. In one embodiment the influenza virus is a 7:1 reassortant, in which only the haemagglutinin gene is derived from a non-pathogenic influenza virus. The virus is useful for production of vaccines against influenza, including influenza caused by highly pathogenic influenza virus strains.

L'invention concerne des vaccins contre le virus de la grippe, et en particulier contre un virus de la grippe réassorti ayant au moins son gène hémagglutinine dérivé d'un virus de la grippe non pathogène ou faiblement pathogène, et ses autres gènes dérivés d'une souche donneuse. Dans une représentation, le virus de la grippe est un virus réassorti 7:1 dans lequel seul le gène hémagglutinine est dérivé d'un virus de la grippe non pathogène. Le virus est utile pour produire des vaccins contre la grippe, y compris la grippe causée par des souches très pathogènes de virus de la grippe.

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