Information processing method for disease stratification and...

G - Physics – 06 – G

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G06G 7/48 (2006.01) G06G 7/58 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2448915

A digital computer system stratifies in a set of patients, based on a set of observations. The observations can include physical, biochemical, histological, genetic, and gene-expression data, among other types of information. Adjustments can be made to account for the possibility that observations of several patients may begin at different points in the progression of their respective disease processes. Once these adjustments are made, the data are subjected to a statistical cluster analysis. Each cluster of patients potentially represents a different disease stratum, with its own underlying cause, optimum therapy, and prognosis. Once the strata are defined and patients are assigned to them, adjustments to the data can be refined. The cluster analysis then can be repeated, and so an iterative process of stratification and staging takes place Fig (5).

Un système informatique numérique effectue la stratification dans une pluralité de patients, sur la base d'un ensemble d'observations. Les observations peuvent comprendre des données physiques, biochimiques, histologiques, génétiques et d'expression génétique, entre autres types d'information. On peut effectuer des ajustements pour prendre en compte la possibilité que les observations de plusieurs patients peuvent avoir des points de départ différents dans l'évolution de leurs maladies respectives. Une fois ces ajustements effectués, on soumet les données à une analyse de groupement. Chaque groupe de patients représente une strate de maladie différente, avec sa propre cause sous-jacente, sa thérapie optimale et son pronostic. Une fois les strates définies et que des patients leur sont affectés, on peut affiner les ajustements aux données. L'analyse de groupement peut alors être répétée, et ainsi on effectue un processus itératif de stratification et de classification par stades.

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